Showing posts with label synthetic life. Show all posts
Showing posts with label synthetic life. Show all posts

Saturday, April 01, 2017

Marching for Science... and then some tech marvels

My science postings used to be free of politics -- and this one will be, in a bit. But how can they be detached, when the central political issue of our time is whether evidence, fact-based argument and truth discovery can survive? I know that on Earth Day (named after my novel, I presume) April 22, I'll join my fellow scientists in the street. 

See more information about the March for Science, as well as satellite marches held around the world. Scientists will speak out and hold events to explain their research to the public. 

Though let me be clear. I also think that marching and protests are secondary. At a moment in history when all fact-professions are under attack, no less than survival is at stake. Marches and protests are like pushing back in a Sumo match. You might gain inches, but what's needed is judo.


How do people comprehend (and trust) science? It's complicated. A recent study has found that people place more confidence in the claims of a popular science article than they do in the claims of an academic article written for experts. They seem to be dissuaded by the academic papers' in-depth discussions of negative results, margins of error, and alternate explanations -- rather than the concise certainties of popularized articles.

 "This emboldens people to reject the ideas of experts who they see as superfluous to their understanding of an idea (which they have already grasped)," writes Scotty Hendricks in Big Think.

== The war is now explicit ==


Through resignations, firings and almost zero replacements, the Trump Administration has all but wiped out the White House Office of Science and Technology Policy, sending it down the path of extinction that — in 1995 — swallowed the congressional Office of Technology Assessment, when Newt Gingrich ruled OTA to be irreparably “partisan.” (As - apparently - are 'facts.') Now members of Mr. Trump’s transition team  have called for getting rid of OSTP, altogether. 

Mr. Trump, says an anonymous official, is still reviewing candidates to be his chief science adviser and he “considers the science and technology office important.” Ah but the two leading candidates for White House Science Advisor - Princeton's William Happer and Yale's David Gelernter - are notorious climate change denialists who regularly express contempt for their scientific peers on abstract and cultural grounds. (I'll be posting about the latter fellow, soon.)

Trump isn’t interested in science and that scientific matters are a low priority at the White House,” said Vinton G. Cerf, a computer scientist, vice president of Google and one of the chief architects of the internet.  Indeed, not one person still working in the science and technology office regularly participates in Mr. Trump’s daily briefings, as they did for President Barack Obama, who more than doubled the OSTP staff, to 130, and moved the office into a building on the White House grounds. (Where I spoke - twice - in 2016 about "big perspectives on threats to civilization."

Obama turned to the science office during crises like the 2014 Ebola outbreak in Africa; the 2011 nuclear spill in Fukushima, Japan; and the Deepwater Horizon oil spill in the Gulf of Mexico in 2010. The staff of the science office developed the White House’s recommendations for regulation of commercial drones and driverless cars at the Transportation Department. Last year, the staff produced an attention-grabbing report that raised concerns about the threat that robots posed to employment and that advocated retraining Americans for higher-skilled jobs. (I participated in an OSTP campaign to get computer programming back into the schools.) The staff also put on the annual White House science fair.

Only now... let's go back to pointing out just how marvelous it is to be a member of a bold, open-minded and scientific civilization. 

== Marvels of research ==

Scientists at The Scripps Research Institute (TSRI) have developed the first stable semi-synthetic organism — a bacterium with two new synthetic bases (called X and Y) added to the four natural bases (A, T, C, and G) that every living organism possesses. Adding two more letters to expand the genetic alphabet can be used to make novel proteins.

Moreover, they found a clever way to ensure that these experimental organisms won't escape the lab. Researchers engineered them to react to a genetic sequence that doesn’t have X and Y as a foreign invader (an immune response).  So any new cell that dropped X and Y would be marked for destruction.  That enabled their semisynthetic organism to keep X and Y in its genome after dividing 60 times, leading the researchers to believe it can hold on to the new base pair indefinitely.

Helping to feed the world? Agronomists have developed a new species: a cross between wheat and its wild cousin, wheat grass - Salish Blue - that's like wheat but grows back year after year, allowing farmers to plow much less and reduce erosion. This holy grail now seems within reach.

An exciting and way overdue international consortium has been formed to develop vaccines much faster. A coalition of governments and charities has committed $460 million to speed up vaccine development for Mers, Lassa fever and Nipah virus. The Coalition for Epidemic Preparedness Innovations (Cepi) aims to have two new experimental vaccines ready for each disease within five years.

The recent discovery of metallic hydrogen could revolutionize many things, especially spaceflight.  

Theoretically predicted a few years ago, ‘time crystals’ are a notion – a new state of matter - that have a structure that repeats in time, not just in space. A time crystal will keep oscillating in its ground state without expending or needing energy, like current in a superfluid. And two teams claim to have made them. “While we're waiting for the papers to be published, we need to be skeptical about the two claims. But the fact that two separate teams have used the same blueprint to make time crystals out of vastly different systems is promising.  

== Scientific nature? ==

According to Bruno Lemaitre, an immunologist at the EPFL research institute in Switzerland, science is filled with “narcissists.” Having read the article, I must respond that this is stunning malarkey and part of the right’s intensely bitter War on Science. And indeed, their war on every single knowledge procession that deals in fact, verification and proof. 

Are there narcissistic scientists? Plenty! They are human and I have known doozies! But scientists are also (in my opinion) the most independent-minded and competitive humans our species ever produced, going at each other with knives of experimentation and scalpels of disproof. All of it moderated by rules of grownup behavior that make us seem all friendly and polite.


No, what the Cultists of the far-far-left and today’s entire right — two wings of a monstrous anti-modernism — share is their desperate need to discredit every profession that does the unforgivable… shines light upon delusion. Science, journalism, teaching, economics, civil servants, medicine… and now the intelligence and military officer corps.
The enemies of maturity and truth use anecdotes to displace statistics. They concoct stories to counter facts. They proclaim — as did the priests and kings of old — “there is no fact! There is only whose voice is loudest!”  Or the best subsidized by today's popes and medicis -- the oligarchy.

== Tech Marvels ==

Oh but we do persevere!  For example, engineers have developed a prototype 3D bioprinter that can create totally functional human skin

Other researchers have pioneered how to regrow bone and the interlaced blood system. 

Several international student hyperloop teams came to SpaceX to compete by hurling their vehicles down the 2nd biggest vacuum chamber in the world.  

Researchers have produced a LED pixel out of nanorods capable of both emitting and detecting light. These nanorods manage to both detect and emit light. Envision Light Fidelity (Li-Fi) technology.  Screens will be able to watch you without a camera and screens could talk to each other.  And yes, we need to talk about this. Openly. Watch the video.

See these amazing photos of one of Greenland’s towns, in an article about the wrangling over the opening of a rare earth elements mine.


Tuesday, July 24, 2012

The First Synthetic Organism: Our Victor Frankenstein Moment?

Remember where you were when you heard or read about this. It’s important.  

In a breakthrough effort for computational biology, the world's first complete computer model of an organism has been completed, Stanford researchers reported last week in the journal Cell. A team used data from more than 900 scientific papers to account for every molecular interaction that takes place in the life cycle of Mycoplasma genitalium, the world's smallest free-living bacterium.

Why is this a whole lot more than your run of the mill bioscience breakthrough?  Until now, knowing the ways and means of a bazillion sub-reactions and gears and wheels did not combine into a clear model of a whole organism. This is a true Frankenstein moment... in the best meaning of the term!  In that before, all we had were countless non-living pieces on the work bench.

Now... we know how to put them together.  Bwa-ha-ha-ha-ha.

No, seriously.  Bwa-haha.

Biologist Craig Venter -- first to sequence the human genome -- has also been at the forefront of this quest to create synthetic life. See his TED Talk: On the Verge of Creating Artificial Life. In his book, Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life, Venter explores these issues -- the challenges and controversies we will face as we head toward biological engineering of genes - and creating digital lifeforms….

Indeed, scientists are now working to create the first digital life form -- by peering into the code of life. OpenWorm is an open source computer simulation aimed at creating a virtual roundworm -- the caenorhabditis elegans (C. elegant), a microscopic nematode. This simulation will encompass every single neuron in the worm, and every connection between neurons.  The result? Watching worm behavior emerge from the data simulation.

In related news: Caltech researchers have created an artificial jellyfish from rat cells and sheets of silicone polymer. It can mimic the swimming motion of natural jellyfish via electrical stimulation which causes rapid contraction of the rat heart muscle cells.

"A powerful demonstration of engineering chimaeric systems of living and non-living components," says Joseph Vacanti of Massachusetts General Hospital. The team hopes to reverse-engineer other marine lifeforms.

Along those lines, take a look at Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves, by George M. Church and Ed Regis -- a look at how scientists will selectively alter the genomes of living organisms to…increase longevity, cure disease or …. even bring back extinct species.


==Science forges on! (Now to get politics to come along)==

Do you wish it were possible to transform American politics enough to calm down the "war on science" and transform it - instead - into a debate about science?

That's one goal of the good folks at Science Debate, who urge that matters of science and technology and the future be put on the agenda of candidates for high office, especially during the looming presidential debates. If we could get just one evening when the focus would be on the very forces -- from energy to innovation, climate change to the internet --  that drive change and propel so many challenges? Front and center? Exposing the intelligent cogency - or lack - in the men seeking to guide us into uncharted waters?  Please visit the site. Even better, sign the petition and viral it.

Barring that brilliant - but alas, unlikely, event - the folks at ScienceDebate.org have polled dozens of top scientific groups to come up with The Top American Science Questions in 2012 -- the most important science policy issues facing the United States.  Whatever your affiliation, this year do spend the time to look them over and then do send them on to your local candidates for Congress and assembly and so on.

Try it.  Then note who actually bothers to answer.

==On the Transparency Front==

BikeCams: Cyclists have long had a rocky coexistence with motorists and pedestrians.  Now some cyclists are wearing helmet-mounted cameras to record their encounters, exactly as portrayed in The Transparent Society.

From baby monitors to closed circuit television, 2.4 GHz video transmitters are in many consumer products these days. And yet, most owners of these video devices don't realize they're transmitting an unencrypted video signal that can be picked up by anyone.

See how one activist is offering these feeds on lamp post boxes to increase public awareness... in stunning correlation with scenes in my new novel EXISTENCE.  In a project, From Surveillance to Broadcast, Benjamin Gaulon has posted boxes on street corners, recording video feed that can be accessed, to increase public awareness of the capabilities of this technology.

No more hiding behind anonymity? YouTube is fighting against idiotic and often nasty/racist/sexist commenters by calling for full names when you upload or comment on videos.  We seem to be caught between a rock and a hard place.  Anonymity protects free speech... and unleashes the most vicious instincts from truly awful people.  Is there any way we could get to hold onto some accountability and feedback loops that encourage maturity and decency... while still keeping the most important benefits of anonymity?  (As it happens, I have a way, and someone could make millions while solving the problem...)

=== A Miscellany of Science News ===

Two shock waves in space, intersecting, might create a “regularity singularity” - interesting general relativity.

The National Ignition Facility completed a 500 terrawatt laser fusion shot. Wow.

Move to Kansas City right now!  Google announced plans to build the gigabit network back in February of 2010 and thousands of municipalities competed to be the future home of the planned network. In March, it selected Kansas City as the first  test of a network running fiber-optic cables directly to homes, and delivering Internet speeds roughly 100 times faster than the national broadband average. Watch for details next week.  (In Existence I briefly describe a completely unused, potentially fecund "right of way" into nearly every home!)

Watch an impressive and inspiring film about cetaceans and research into whales - with unbelievable photography - by Fabrice Schnoller and a team of French researchers.

Yes... science marches on.  Let's stay worthy of it.